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This reactive epoxide intermediate may perhaps respond with amino acid residues of the CYP enzyme to kind drug-CYP (drug-protein) adducts (Plan six, pathway C). The formation with the drug-CYP adducts might or might not show a time-dependent inactivation of your catalytic exercise of this CYP enzyme

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HPLC can different and detect Every compound by the real difference of each compound's velocity through the column. Fig.3 demonstrates an example of HPLC separation. When an analyte passes in the sample movement mobile, the refractive index, and direction of The sunshine In the stream cel